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nfx1 database  (Human Protein Atlas)

 
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    Human Protein Atlas nfx1 database
    <t>NFX1-123</t> and proliferation and differentiation marker protein expression in HPV16 positive cervical cancer tissues. ( A ) Immunohistochemical staining of NFX1-123, Notch1, Ki67, and Keratin 1 in HPV16 positive cervical tumors (n = 34). Representative images of high, medium, and low staining are shown for each protein. Number of tumors and corresponding percent of total tumors graded as high, medium, or low staining were quantified and shown in graphs (right). ( B ) Heat map representation of the NFX1-123, Notch1, Ki67 and Keratin 1 expression in cervical cancer samples (n = 34) and normal cervical epithelial samples (n = 31). The cervical tumors are clustered by histologic classification (carcinoma in situ (CIS), moderately differentiated, poorly differentiated, or invasive squamous cell carcinomas (SCC)) and the normal cervical tissues clustered by cytologic classification (negative or reactive cellular changes). The staining intensity of both the HPV 16 positive cervical cancers and the normal cervical specimens were converted to a four-point colorimetric scale: 1= non-detected, 2 = low, 3 = medium, 4 = high.
    Nfx1 Database, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nfx1 database/product/Human Protein Atlas
    Average 90 stars, based on 1 article reviews
    nfx1 database - by Bioz Stars, 2026-03
    90/100 stars

    Images

    1) Product Images from "Genes Regulated by HPV 16 E6 and High Expression of NFX1-123 in Cervical Cancers"

    Article Title: Genes Regulated by HPV 16 E6 and High Expression of NFX1-123 in Cervical Cancers

    Journal: OncoTargets and therapy

    doi: 10.2147/OTT.S251926

    NFX1-123 and proliferation and differentiation marker protein expression in HPV16 positive cervical cancer tissues. ( A ) Immunohistochemical staining of NFX1-123, Notch1, Ki67, and Keratin 1 in HPV16 positive cervical tumors (n = 34). Representative images of high, medium, and low staining are shown for each protein. Number of tumors and corresponding percent of total tumors graded as high, medium, or low staining were quantified and shown in graphs (right). ( B ) Heat map representation of the NFX1-123, Notch1, Ki67 and Keratin 1 expression in cervical cancer samples (n = 34) and normal cervical epithelial samples (n = 31). The cervical tumors are clustered by histologic classification (carcinoma in situ (CIS), moderately differentiated, poorly differentiated, or invasive squamous cell carcinomas (SCC)) and the normal cervical tissues clustered by cytologic classification (negative or reactive cellular changes). The staining intensity of both the HPV 16 positive cervical cancers and the normal cervical specimens were converted to a four-point colorimetric scale: 1= non-detected, 2 = low, 3 = medium, 4 = high.
    Figure Legend Snippet: NFX1-123 and proliferation and differentiation marker protein expression in HPV16 positive cervical cancer tissues. ( A ) Immunohistochemical staining of NFX1-123, Notch1, Ki67, and Keratin 1 in HPV16 positive cervical tumors (n = 34). Representative images of high, medium, and low staining are shown for each protein. Number of tumors and corresponding percent of total tumors graded as high, medium, or low staining were quantified and shown in graphs (right). ( B ) Heat map representation of the NFX1-123, Notch1, Ki67 and Keratin 1 expression in cervical cancer samples (n = 34) and normal cervical epithelial samples (n = 31). The cervical tumors are clustered by histologic classification (carcinoma in situ (CIS), moderately differentiated, poorly differentiated, or invasive squamous cell carcinomas (SCC)) and the normal cervical tissues clustered by cytologic classification (negative or reactive cellular changes). The staining intensity of both the HPV 16 positive cervical cancers and the normal cervical specimens were converted to a four-point colorimetric scale: 1= non-detected, 2 = low, 3 = medium, 4 = high.

    Techniques Used: Marker, Expressing, Immunohistochemical staining, Staining, In Situ

    NFX1 and NFX1L1 mRNA and protein expression was upregulated in cervical and head and neck cancers. ( A ) mRNA expression of NFX1 and NFX1L1 in normal cervix (n = 10) and cervical primary tumors (n = 303) from TCGA Target GTEx database were plotted for graphical presentation using GraphPad Prism. ( B ) IHC analysis of NFX1 protein expression in normal cervical tissues (n = 3) and cervical tumors (n = 11) from The Human Protein Atlas database. Representative images of normal cervical tissue and cervical tumors are shown. M = medium staining intensity, H = high. Number of tumors and corresponding percent of total tumors graded as high or medium were quantified and shown in graphs (right).
    Figure Legend Snippet: NFX1 and NFX1L1 mRNA and protein expression was upregulated in cervical and head and neck cancers. ( A ) mRNA expression of NFX1 and NFX1L1 in normal cervix (n = 10) and cervical primary tumors (n = 303) from TCGA Target GTEx database were plotted for graphical presentation using GraphPad Prism. ( B ) IHC analysis of NFX1 protein expression in normal cervical tissues (n = 3) and cervical tumors (n = 11) from The Human Protein Atlas database. Representative images of normal cervical tissue and cervical tumors are shown. M = medium staining intensity, H = high. Number of tumors and corresponding percent of total tumors graded as high or medium were quantified and shown in graphs (right).

    Techniques Used: Expressing, Staining

    mRNA expression of genes regulated by HPV 16E6 and NFX1-123 were significantly upregulated in cervical cancer. mRNA expression of 19 genes regulated by 16E6 and NFX1-123 were analyzed using TCGA Target TGEx in normal cervix (n = 10) compared to cervical primary tumors (n = 303). Significance was determined using two-tailed Mann–Whitney test. 14 of 19 genes were significantly upregulated in cervical tumors compared to normal tissue. LOR, CEBPD, LCE2B, FOXA 2, and FBN2 were deregulated in cervical cancers, although they did not reach statistical significance. Note the Y-axis scales for individual gene expression datasets were adjusted to demonstrate samples with no detectable gene expression (0 value).
    Figure Legend Snippet: mRNA expression of genes regulated by HPV 16E6 and NFX1-123 were significantly upregulated in cervical cancer. mRNA expression of 19 genes regulated by 16E6 and NFX1-123 were analyzed using TCGA Target TGEx in normal cervix (n = 10) compared to cervical primary tumors (n = 303). Significance was determined using two-tailed Mann–Whitney test. 14 of 19 genes were significantly upregulated in cervical tumors compared to normal tissue. LOR, CEBPD, LCE2B, FOXA 2, and FBN2 were deregulated in cervical cancers, although they did not reach statistical significance. Note the Y-axis scales for individual gene expression datasets were adjusted to demonstrate samples with no detectable gene expression (0 value).

    Techniques Used: Expressing, Two Tailed Test, MANN-WHITNEY, Gene Expression

    HPV 16E6/NFX1-123 regulated proteins were differentially expressed in cervical cancers. Relative expression of nine 16E6/NFX1-123 regulated proteins were compared in cervical tumors and normal cervical samples from The Human Protein Atlas database. Representative images of the IHC staining for the 9 genes are shown for normal cervix (left) or for cervical tumors (middle panels). Number of tumors and corresponding percent of total tumors graded as high, medium, or low staining were quantified and shown in graphs (right). Abbreviations: ND, not detected; L, low; M, medium; H, high.
    Figure Legend Snippet: HPV 16E6/NFX1-123 regulated proteins were differentially expressed in cervical cancers. Relative expression of nine 16E6/NFX1-123 regulated proteins were compared in cervical tumors and normal cervical samples from The Human Protein Atlas database. Representative images of the IHC staining for the 9 genes are shown for normal cervix (left) or for cervical tumors (middle panels). Number of tumors and corresponding percent of total tumors graded as high, medium, or low staining were quantified and shown in graphs (right). Abbreviations: ND, not detected; L, low; M, medium; H, high.

    Techniques Used: Expressing, Immunohistochemistry, Staining

    Protein expression of genes upregulated with overexpressed NFX1-123 and 16E6 in HPV positive cell lines. Western blot analysis of NFX1-123 and 16E6 regulated proteins ( A ) RAET1G and Notch1 ( B ) TGM1 and ( C ) FOXA2 in primary human foreskin keratinocytes (HFK), HPV 16 positive cervical cancer cell lines (SiHa and CaSki), and a HPV 18 positive cervical cancer cell line (HeLa). Beta-actin was used as a loading control. Fold expression of each protein of interest is shown for these cervical cancer cell lines relative to typical expression in HFKs.
    Figure Legend Snippet: Protein expression of genes upregulated with overexpressed NFX1-123 and 16E6 in HPV positive cell lines. Western blot analysis of NFX1-123 and 16E6 regulated proteins ( A ) RAET1G and Notch1 ( B ) TGM1 and ( C ) FOXA2 in primary human foreskin keratinocytes (HFK), HPV 16 positive cervical cancer cell lines (SiHa and CaSki), and a HPV 18 positive cervical cancer cell line (HeLa). Beta-actin was used as a loading control. Fold expression of each protein of interest is shown for these cervical cancer cell lines relative to typical expression in HFKs.

    Techniques Used: Expressing, Western Blot, Control



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    nfx1 database  (Human Protein Atlas)
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    Human Protein Atlas nfx1 database
    <t>NFX1-123</t> and proliferation and differentiation marker protein expression in HPV16 positive cervical cancer tissues. ( A ) Immunohistochemical staining of NFX1-123, Notch1, Ki67, and Keratin 1 in HPV16 positive cervical tumors (n = 34). Representative images of high, medium, and low staining are shown for each protein. Number of tumors and corresponding percent of total tumors graded as high, medium, or low staining were quantified and shown in graphs (right). ( B ) Heat map representation of the NFX1-123, Notch1, Ki67 and Keratin 1 expression in cervical cancer samples (n = 34) and normal cervical epithelial samples (n = 31). The cervical tumors are clustered by histologic classification (carcinoma in situ (CIS), moderately differentiated, poorly differentiated, or invasive squamous cell carcinomas (SCC)) and the normal cervical tissues clustered by cytologic classification (negative or reactive cellular changes). The staining intensity of both the HPV 16 positive cervical cancers and the normal cervical specimens were converted to a four-point colorimetric scale: 1= non-detected, 2 = low, 3 = medium, 4 = high.
    Nfx1 Database, supplied by Human Protein Atlas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/nfx1 database/product/Human Protein Atlas
    Average 90 stars, based on 1 article reviews
    nfx1 database - by Bioz Stars, 2026-03
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    NFX1-123 and proliferation and differentiation marker protein expression in HPV16 positive cervical cancer tissues. ( A ) Immunohistochemical staining of NFX1-123, Notch1, Ki67, and Keratin 1 in HPV16 positive cervical tumors (n = 34). Representative images of high, medium, and low staining are shown for each protein. Number of tumors and corresponding percent of total tumors graded as high, medium, or low staining were quantified and shown in graphs (right). ( B ) Heat map representation of the NFX1-123, Notch1, Ki67 and Keratin 1 expression in cervical cancer samples (n = 34) and normal cervical epithelial samples (n = 31). The cervical tumors are clustered by histologic classification (carcinoma in situ (CIS), moderately differentiated, poorly differentiated, or invasive squamous cell carcinomas (SCC)) and the normal cervical tissues clustered by cytologic classification (negative or reactive cellular changes). The staining intensity of both the HPV 16 positive cervical cancers and the normal cervical specimens were converted to a four-point colorimetric scale: 1= non-detected, 2 = low, 3 = medium, 4 = high.

    Journal: OncoTargets and therapy

    Article Title: Genes Regulated by HPV 16 E6 and High Expression of NFX1-123 in Cervical Cancers

    doi: 10.2147/OTT.S251926

    Figure Lengend Snippet: NFX1-123 and proliferation and differentiation marker protein expression in HPV16 positive cervical cancer tissues. ( A ) Immunohistochemical staining of NFX1-123, Notch1, Ki67, and Keratin 1 in HPV16 positive cervical tumors (n = 34). Representative images of high, medium, and low staining are shown for each protein. Number of tumors and corresponding percent of total tumors graded as high, medium, or low staining were quantified and shown in graphs (right). ( B ) Heat map representation of the NFX1-123, Notch1, Ki67 and Keratin 1 expression in cervical cancer samples (n = 34) and normal cervical epithelial samples (n = 31). The cervical tumors are clustered by histologic classification (carcinoma in situ (CIS), moderately differentiated, poorly differentiated, or invasive squamous cell carcinomas (SCC)) and the normal cervical tissues clustered by cytologic classification (negative or reactive cellular changes). The staining intensity of both the HPV 16 positive cervical cancers and the normal cervical specimens were converted to a four-point colorimetric scale: 1= non-detected, 2 = low, 3 = medium, 4 = high.

    Article Snippet: Supporting this, 100% of the cervical tumors in the Human Protein Atlas database had medium to high expression of NFX1 (n=11) ( ).

    Techniques: Marker, Expressing, Immunohistochemical staining, Staining, In Situ

    NFX1 and NFX1L1 mRNA and protein expression was upregulated in cervical and head and neck cancers. ( A ) mRNA expression of NFX1 and NFX1L1 in normal cervix (n = 10) and cervical primary tumors (n = 303) from TCGA Target GTEx database were plotted for graphical presentation using GraphPad Prism. ( B ) IHC analysis of NFX1 protein expression in normal cervical tissues (n = 3) and cervical tumors (n = 11) from The Human Protein Atlas database. Representative images of normal cervical tissue and cervical tumors are shown. M = medium staining intensity, H = high. Number of tumors and corresponding percent of total tumors graded as high or medium were quantified and shown in graphs (right).

    Journal: OncoTargets and therapy

    Article Title: Genes Regulated by HPV 16 E6 and High Expression of NFX1-123 in Cervical Cancers

    doi: 10.2147/OTT.S251926

    Figure Lengend Snippet: NFX1 and NFX1L1 mRNA and protein expression was upregulated in cervical and head and neck cancers. ( A ) mRNA expression of NFX1 and NFX1L1 in normal cervix (n = 10) and cervical primary tumors (n = 303) from TCGA Target GTEx database were plotted for graphical presentation using GraphPad Prism. ( B ) IHC analysis of NFX1 protein expression in normal cervical tissues (n = 3) and cervical tumors (n = 11) from The Human Protein Atlas database. Representative images of normal cervical tissue and cervical tumors are shown. M = medium staining intensity, H = high. Number of tumors and corresponding percent of total tumors graded as high or medium were quantified and shown in graphs (right).

    Article Snippet: Supporting this, 100% of the cervical tumors in the Human Protein Atlas database had medium to high expression of NFX1 (n=11) ( ).

    Techniques: Expressing, Staining

    mRNA expression of genes regulated by HPV 16E6 and NFX1-123 were significantly upregulated in cervical cancer. mRNA expression of 19 genes regulated by 16E6 and NFX1-123 were analyzed using TCGA Target TGEx in normal cervix (n = 10) compared to cervical primary tumors (n = 303). Significance was determined using two-tailed Mann–Whitney test. 14 of 19 genes were significantly upregulated in cervical tumors compared to normal tissue. LOR, CEBPD, LCE2B, FOXA 2, and FBN2 were deregulated in cervical cancers, although they did not reach statistical significance. Note the Y-axis scales for individual gene expression datasets were adjusted to demonstrate samples with no detectable gene expression (0 value).

    Journal: OncoTargets and therapy

    Article Title: Genes Regulated by HPV 16 E6 and High Expression of NFX1-123 in Cervical Cancers

    doi: 10.2147/OTT.S251926

    Figure Lengend Snippet: mRNA expression of genes regulated by HPV 16E6 and NFX1-123 were significantly upregulated in cervical cancer. mRNA expression of 19 genes regulated by 16E6 and NFX1-123 were analyzed using TCGA Target TGEx in normal cervix (n = 10) compared to cervical primary tumors (n = 303). Significance was determined using two-tailed Mann–Whitney test. 14 of 19 genes were significantly upregulated in cervical tumors compared to normal tissue. LOR, CEBPD, LCE2B, FOXA 2, and FBN2 were deregulated in cervical cancers, although they did not reach statistical significance. Note the Y-axis scales for individual gene expression datasets were adjusted to demonstrate samples with no detectable gene expression (0 value).

    Article Snippet: Supporting this, 100% of the cervical tumors in the Human Protein Atlas database had medium to high expression of NFX1 (n=11) ( ).

    Techniques: Expressing, Two Tailed Test, MANN-WHITNEY, Gene Expression

    HPV 16E6/NFX1-123 regulated proteins were differentially expressed in cervical cancers. Relative expression of nine 16E6/NFX1-123 regulated proteins were compared in cervical tumors and normal cervical samples from The Human Protein Atlas database. Representative images of the IHC staining for the 9 genes are shown for normal cervix (left) or for cervical tumors (middle panels). Number of tumors and corresponding percent of total tumors graded as high, medium, or low staining were quantified and shown in graphs (right). Abbreviations: ND, not detected; L, low; M, medium; H, high.

    Journal: OncoTargets and therapy

    Article Title: Genes Regulated by HPV 16 E6 and High Expression of NFX1-123 in Cervical Cancers

    doi: 10.2147/OTT.S251926

    Figure Lengend Snippet: HPV 16E6/NFX1-123 regulated proteins were differentially expressed in cervical cancers. Relative expression of nine 16E6/NFX1-123 regulated proteins were compared in cervical tumors and normal cervical samples from The Human Protein Atlas database. Representative images of the IHC staining for the 9 genes are shown for normal cervix (left) or for cervical tumors (middle panels). Number of tumors and corresponding percent of total tumors graded as high, medium, or low staining were quantified and shown in graphs (right). Abbreviations: ND, not detected; L, low; M, medium; H, high.

    Article Snippet: Supporting this, 100% of the cervical tumors in the Human Protein Atlas database had medium to high expression of NFX1 (n=11) ( ).

    Techniques: Expressing, Immunohistochemistry, Staining

    Protein expression of genes upregulated with overexpressed NFX1-123 and 16E6 in HPV positive cell lines. Western blot analysis of NFX1-123 and 16E6 regulated proteins ( A ) RAET1G and Notch1 ( B ) TGM1 and ( C ) FOXA2 in primary human foreskin keratinocytes (HFK), HPV 16 positive cervical cancer cell lines (SiHa and CaSki), and a HPV 18 positive cervical cancer cell line (HeLa). Beta-actin was used as a loading control. Fold expression of each protein of interest is shown for these cervical cancer cell lines relative to typical expression in HFKs.

    Journal: OncoTargets and therapy

    Article Title: Genes Regulated by HPV 16 E6 and High Expression of NFX1-123 in Cervical Cancers

    doi: 10.2147/OTT.S251926

    Figure Lengend Snippet: Protein expression of genes upregulated with overexpressed NFX1-123 and 16E6 in HPV positive cell lines. Western blot analysis of NFX1-123 and 16E6 regulated proteins ( A ) RAET1G and Notch1 ( B ) TGM1 and ( C ) FOXA2 in primary human foreskin keratinocytes (HFK), HPV 16 positive cervical cancer cell lines (SiHa and CaSki), and a HPV 18 positive cervical cancer cell line (HeLa). Beta-actin was used as a loading control. Fold expression of each protein of interest is shown for these cervical cancer cell lines relative to typical expression in HFKs.

    Article Snippet: Supporting this, 100% of the cervical tumors in the Human Protein Atlas database had medium to high expression of NFX1 (n=11) ( ).

    Techniques: Expressing, Western Blot, Control